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Hypertensive" refers to high blood pressure and "nephropathy" means damage to the kidney; hence this condition is where chronic high blood pressure causes damages to kidney tissue; this includes the small blood vessels, glomeruli, kidney tubules and interstitial tissues. The tissue hardens and thickens which is known as nephrosclerosis .
The diagnosis of hypertensive nephrosclerosis is generally inferred from the characteristic clinical features. Other obvious causes of kidney disease should be excluded, especially bilateral renal artery stenosis.Effective treatment of the hypertension usually slows progression of kidney injury.